It includes a set of Franz-type vertical diffusion chambers and a thermostat coupled to an automatic acceptor fluid intake. Company: Hanson Microette TM Topical & Transdermal Diffusion Cell System, Hanson Research. Corporation, USA. The system is used in studies to evaluate: the barrier properties of human skin, the ability of substances to penetrate the skin, as well as to understand the kinetics of diffusion of this process. Biological samples (ex-vivo skin) as well as synthetic membranes (artificial skin) can be used. It is possible to verify the capacity for absorption into the body of, for example, therapeutic or toxic substances via blood or lymphatic vessels located in the skin. The system allows pharmacokinetic testing at pre-programmed intervals. The system is also used to assess pharmaceutical availability from medicinal formulations on the skin as well as cosmetic formulations (ointments, creams, emulsions) or plant extracts directly. The system complies with pharmacopoeial and US Food and Drug Administration - FDA requirements.
The apparatus is available for use after agreeing its availability with the laboratory manager. Both scientific cooperation and commercial use is possible, and access is determined separately for each project in accordance with its specificity.