DXR Smart Raman spectrometer

Description

Raman spectrometer DXR Smart Raman is an apparatus that allows obtaining the Raman spectrum of solid (including powdered) or liquid samples (including aqueous solutions). The instrument is equipped with a DXR 780 nm laser with a maximum power of 18 mW, a Raleigh filter and CCD detector. The maximum measurement range is 3414 - 38 cm-1 using an aperture of 25 or 50 μm. Raman spectroscopy is used in particular to establish or confirm the identity of substances, study polymorphism and amorphous forms, phase transformations, dispersion constants, cocrystals, detect incompatibilities between components and determine the composition of solid dispersion systems.

Examples of research articles:
Publications

"Arbidol hydrochloride compatibility study with starchy excipients using DSC, FTIR, TGA-FTIR, and PXRD methods. Rojek B., Bartyzel A., Leyk E., Plenis A. J Therm Anal Calorim 2025. https://doi.org/10.1007/s10973-025-14056-4
DSC, TGA-FTIR and FTIR Assisted by Chemometric Factor Analysis and PXRD in Assessing the Incompatibility of the Antiviral Drug Arbidol Hydrochloride with Pharmaceutical Excipients. Rojek B., Bartyzel A., Sawicki W., Plenis A. Molecules 2024, 29, 264. https://doi.org/10.3390/molecules29010264
Stability of Paracetamol Amorphized by Co-Melting with Various Cellulose Derivatives, Leyk E., Plenis A., Kasprowicz J., Dziurkowska E. Appl. Sci. 2024, 14, 6709. https://doi.org/10.3390/app14156709
A combined differential scanning calorimetry and thermogravimetry approach for the effective assessment of drug substance-excipient compatibility. Rojek B., Wesołowski M. J Therm Anal Calorim 2023, 148, 845–858. https://doi.org/10.1007/s10973-022-11849-9.
The effect of cellulose derivatives on paracetamol crystallinity reduction. Leyk E., Wesolowski M. J Therm Anal Calorim 2022, 147, 10037–10048. https://doi.org/10.1007/s10973-022-11312-9.
Quantification of Compatibility Between Polymeric Excipients and Atenolol Using Principal Component Analysis and Hierarchical Cluster Analysis. Rojek B., Gazda M. Wesołowski M. AAPS PharmSciTech, 2022, 23, 3. https://doi.org/10.1208/s12249-021-02143-2.
New Saccharin Salt of Chlordiazepoxide: Structural and Physicochemical Examination. Lech A., Garbacz P., Sikorski A., Gazda M., Wesołowski M. Int J Mol Sci. 2022, 23(19), 12050. doi: 10.3390/ijms231912050.
Miscibility and Solubility of Caffeine and Theophylline in Hydroxypropyl Methylcellulose. Leyk E., Wesołowski M. Pharmaceutics 2021, 13, 1836. https://doi.org/10.3390/pharmaceutics13111836.
Compatibility study of theophylline with excipients using thermogravimetry supported by kinetic analysis. Rojek B., Wesołowski M. J Therm Anal Calorim, 2021, 143, 227–236. https://doi.org/10.1007/s10973-019-09235-z.
Benzodiazepines co-crystals screening using FTIR and Raman spectroscopy supported by differential scanning calorimetry. Garbacz P., Wesołowski M. Spectrochim Acta A Mol Biomol Spectrosc.2020, 234, 118242. doi: 10.1016/j.saa.2020.118242.
Structural characterization of co-crystals of chlordiazepoxide with p-aminobenzoic acid and lorazepam with nicotinamide by DSC, X-ray diffraction, FTIR and Raman spectroscopy. Garbacz P., Paukszta D., Sikorski A., Wesołowski M. Pharmaceutics, 2020, 12, 648.
DSC supported by factor analysis as a reliable tool for compatibility study in pharmaceutical mixtures. Rojek B., Wesołowski M. J Therm Anal Calorim 2019, 138, 4531–4539. https://doi.org/10.1007/s10973-019-08223-7.
FTIR and TG analyses coupled with factor analysis in a compatibility study of acetazolamide with excipients. Rojek B, Wesołowski M. Spectrochim Acta A Mol Biomol Spectrosc. 2019, 208, 285-293. doi: 10.1016/j.saa.2018.10.020.
Interactions Between Paracetamol and Hypromellose in the Solid State. Leyk E, Wesołowski M. Front Pharmacol. 2019, 10, 14. doi: 10.3389/fphar.2019.00014.
Artificial neural networks as a supporting tool for compatibility study based on thermogravimetric data. Rojek B., Suchacz B., Wesołowski M. Thermochimica Acta, 2018, 659, 222-231.
DSC as a screening tool for rapid co-crystal detection in binary mixtures of benzodiazepines with co-formers. Saganowska P., Wesołowski M. J. Therm. Anal. Calorim. 2018, 133, 785-795.
DSC, FTIR and Raman Spectroscopy Coupled with Multivariate Analysis in a Study of Co-Crystals of Pharmaceutical Interest. Garbacz, P., Wesołowski, M. Molecules 2018, 23, 2136. https://doi.org/10.3390/molecules23092136"

Details

Type of infrastructure:
large research equipment
Strategic infrastructure:
Yes
Accessibility
scientific research

Manager / operator

Manager

Manager's name
Dr. Habil. Alina Plenis, Assoc. Prof.
Manager's e-mail
alina.plenis@gumed.edu.pl
Manager's phone
583491096

Operator

Operator's name
Edyta Leyk, Pharm.D.
Operator's e-mail
edyta.leyk@gumed.edu.p
Operator's phone
583491526

Manufacturer

Manufacturer
Thermo Scientific
Year of production
2010

Laboratory where the equipment is located

Name of the laboratory
Laboratory of spectroscopic analysis

Location

University
Medical University of Gdańsk
Organisational Unit
Department of Analytical Chemistry
Street
Al. Gen. J. Hallera, 107
Postal Code
80-416
City
Gdańsk
Room
223a

Access rules

Access rules

Access to the instrument is possible upon prior individual arrangement of availability and terms of use with the laboratory manager.