Tomocube tomographic microscope

Tomocube is an advanced microscope utilizing 3D holotomography (HT) technology, which combines holography and tomography to recreate a three-dimensional map of the refractive index (3D RI tomogram) of living cells and tissues. This technique enables non-invasive, label-free imaging of cells in real time, providing detailed data on morphology and intracellular structures such as the nucleus, mitochondria, and lipid droplets.

Examples of research articles:

Publications

Kobiela A, Klimczuk M, Serafin PK, Kitowska K, Biernacka A, Abouali R, de la Serna JB, Wang X, Gajdowska F, Kosobucka A, Siedlar AM, Hauer A, Hovhannisyan L, Bogucka A, Smits JPH, van den Bogaard EH, Sądej R, Ogg GS, Gutowska-Owsiak D. Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions. BMC Biol. 2026 Jan 8;24(1):30. doi: 10.1186/s12915-025-02499-y. PMID: 41507905; PMCID: PMC12874910.